Explaining additional genetic variation in complex traits
نویسندگان
چکیده
منابع مشابه
Patterns of genetic variation in Mendelian and complex traits.
This review discusses the prospects for understanding the genetic basis of complex traits in humans. We take the view that work done on Drosophila melanogaster can serve as a model for understanding complex traits in humans, and the literature on this model system, as well as on humans, is reviewed. The prospects for success in understanding the genetic basis of complex traits depend, in part, ...
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Genome-wide association studies and, more recently, next-generation sequencing studies have accelerated the investigation of complex human traits by providing a wealth of association data linking genetic variants to diseases and other phenotypic traits. These data promise to transform our understanding of the molecular pathways underlying complex human traits, but only if functional evaluation ...
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Iris belongs toIridaceae family and it is monocotyledon. Iris is one of the important ornamental and medicinal plants. 34 iris genotypes (14 species) collected from different provinces of Iran were planted at National Institute of Ornamental Plants (NIOP) Iran. All of the species evaluated for 15 quantitative traits and 30 qualitative traits. Results showed that the highest positive correlation...
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The functional characterization of genes involved in many complex traits (phenotypes) of plants, animals, or humans can be studied from a computational point of view using different tools. We propose prediction--from the machine learning point of view--to search for the genetic basis of these traits. However, trying to predict an exact value of a phenotype can be too difficult to obtain a confi...
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ژورنال
عنوان ژورنال: Trends in Genetics
سال: 2014
ISSN: 0168-9525
DOI: 10.1016/j.tig.2014.02.003